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For now, we will simply observe that if electron transport is inhibited for some reason, yet the NADH/NAD + ratio remains significantly elevated above its equilibrium mass action ratio, then electrons may leave the electron transport chain and move onto O 2 to create O 2 .- Other physiologic changes in mitochondria may also increase ROS generation without necessarily dramatically affecting oxidative phosphorylation

62 and performed as described previously (11, 63)

426 Furthermore, Listeria strains engineered to deliver galactosylceramide have been shown to increase natural killer T-cell activity and reduce metastasis in mouse breast tumor models

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