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(2010) reported that iPSC-derived grafts can differentiate into neurons, astrocytes, and OLs

The accumulation of misfolded or unfolded proteins may perturb ER function and result in ER stress and activation of the UPR, in an attempt to rescue or dispose of the burden of misfolded proteins (48,49)

R The glutathione conjugate is then processed through the mercapturic acid pathway: gamma-glutamyl transpeptidase (GGT) on the external surface of renal and biliary epithelia cleaves the gamma-glutamyl bond, aminopeptidase M removes glycine, and cytosolic N-acetyltransferase acetylates the remaining cysteine to form the mercapturic acid

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The in vitro antioxidant assays revealed that all the components possessed the ability to scavenge DPPH, OH, and O 2 radicals, as well as to reduce ferric ions