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In fact, accumulation of NMN in nerve injury promotes axonal degeneration (Di Stefano et al., 2015) and NMN deamidase delays Wallerian degeneration and rescues axonal outgrowth defects (Di Stefano et al., 2017)

& Ma, F

& Appel, S

An early molecular component of the wound healing response in rat embryos induction of c-fos protein in cells at the epidermal wound margin

Conclusions and future perspective After over 110 years since its initial discovery, NAD + is emerging as a central metabolite in life science field, and altered NAD + homeostasis is becoming an established common feature of multiple pathologic diseases