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Nitric oxide (NO) is a free radical gas molecule produced endogenously from L-arginine, oxygen, and NADPH by an enzyme nitric oxide synthase (NOS) [139]

Conclusion: While steatosis adjustment has been proposed to measure fibrosis change independent of changes in steatosis, it poses a risk of overestimating fibrosis reduction if any amount of steatosis region reverts to normal tissuepotentially leading to falsely identifying a response in some patients