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Deletion of nuclear factor ImerC (NFI-C) leads to overexpression of plasminogen activator I (PAI-1) and subsequent inhibition of uPA activity and HGF signal, thus impairing hepatocyte proliferation (Marubashi et al., 2004)

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[28] From a mechanistic perspective, if the enzyme adds hydride to the re face of NAD + , the resulting hydrogen is incorporated into the pro-R position