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Astrocytes supply neurons with antioxidants like glutathione and facilitate cerebrospinal and interstitial fluid movement to remove metabolic waste

Khan A, Khan MI, Iqbal Z, Shah Y, Ahmad L, Nazir S, Wason DG, Khan JA, Nasir F, Ismail

These changes hinder nutrient and water uptake, further intensifying stress, as observed in various plants under stress conditions [10, 40, 41]

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We propose to investigate therapies that contribute to the current state of this problem using a model of sAD in rats based on a single intracerebroventricular (icv) injection of streptozotocin (STZ)