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doi: 10.1016/j.cell.2012.03.042 4 ChenXLiJKangRKlionskyDJTangD

The SASP is regulated by complex signaling networks, often involving transcription factors like NF-B and C/EBP, and can be reinforced by autocrine feedback loops involving factors like IL-1 [20]

However, how the dynamic of NADPH consumption mediates the co-regulation between individual inflammatory and anti-inflammatory pathways is only beginning to be appreciated