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The metabolism and clearance of both components may be affected by significant liver disease, and patients with severe hepatic impairment should be monitored closely if treatment is deemed necessary

"Labs studying NNMT and methyl donor dependent pathways need more than a label and a purity statement, they need a clear picture of how a compound behaves across the full workflow from storage and preparation to assay readout," said Samuel Yanner, Director of Scientific Operations at Umbrella Labs