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Additionally, it is contraindicated in patients with megaloblastic anemia due to vitamin B12 deficiency without concurrent folate deficiency

Figure 5 Functional enrichment analysis of DEG identified in the contrasts above mentioned revealed 90 metabolic and signaling pathways differentially regulated in the groups MOD or SEV at endpoint A directly or indirectly related to the inflammatory response in blood, although patients had received glucocorticoid treatment for approximately 11 days prior to collection of samples to the study ( Figure 6A and Figure S4 )