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Within hours after cleaning, teeth become coated with a layer of salivary proteins, which can isolate antibacterial materials from bacteria, thereby reducing antimicrobial efficiency and long-term efficacy ( In addition to the two aforementioned oral-specific environmental resistance factors, the clinical translation of nanomaterials currently faces several challenges:(1) the long-term biosafety, biocompatibility, and functional durability of these nanomaterials within the oral cavity require rigorous assessment in live animal models and, ultimately, clinical trials ( in vitro

Natural Product Derivatives 20 (6), 454457

Finally, the third burst of ERK1/2 activation associated with G2/M progression 34 was also greatly diminished and associated with a reduced number of cells replicating DNA and progressing in G2 and M phases

NRF2 SUMOylation is mediated by a sequential enzymatic process involving the SUMO-activating enzyme E1, the SUMO-conjugating enzyme E2, and the SUMO ligase E3 [128]

Metastasis 32 , 605622 (2015)