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Furthermore, heterogeneity in tumour stage (or indeed, location), patient populations and treatment dose and duration is likely to confound reported response data, particularly given the links between changes in oxidative metabolism and metastatic spread 84,85,86,87

Such mutations frequently occur in mononucleotide repeat regions, exemplified by the D310 region, where insertions and deletions in tumor mtDNA have been widely reported and shown to be significantly associated with late-stage disease and poor prognosis [144,145,146]