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Synergistic effect of otoprotectant drugs and natural product (Table 2) N-acetylcysteine (NAC) is a precursor to GSH, a ubiquitous thiol-containing antioxidant and a widely used cytoprotectant with a promising hearing protective effect (Wu et al

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These data suggest that ethanol decreases cysteine through a disrupted methionine cycle and transsulfuration pathway, ultimately leading to GSH exhaustion

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