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Regional Disciplinary Medical Board: vitamin B12 cannot be overdosed In 2009, the Regional Disciplinary Medical Board in Eindhoven stated very clearly that an overdose is not possible: There can be no question of an overdose of hydroxocobalamin, as the excess is excreted in urine by the kidneys and therefore cannot accumulate in the body

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The clinical implications, however, depend on whether the mechanism translates to humans and whether the doses used produce meaningful c-Met activation in human brain tissue

If you are not very B12 deficient or not experiencing fatigue or nerve sensations as one of your symptoms, you may not notice the benefits until after youve had 2-3 injections over several weeks

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