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FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation

Extracellular vesicles encapsulated with caspase-1 inhibitor ameliorate experimental autoimmune myasthenia gravis through targeting macrophages

In parallel, the increased Kyn/Trp ratio in symptomatic patients supports the presence of inflammatory activation

Since aerobic glycolysis represents a hallmark of metabolic reprogramming that sustains tumor growth 37 , these results highlight a previously unrecognized metabolic role of MAT2A in OS