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In addition, the use of valproic acid with or without other anticonvulsants may cause hepatotoxicity and increase plasma ammonia concentrations, leading to encephalopathy

2014 Oct;74(4):875-82

High-fat diet-induced lysosomal dysfunction and impaired autophagic flux contribute to lipotoxicity in the kidney

In 2009, the Food and Drug Administration (FDA) warned consumers about the potential for serious adverse effects associated with the consumption of hydroxycut, a popular HCA-containing slimming pill