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Research has characterised MT-1s ability to confer photoprotection through mechanisms operating independently of melanin synthesis , documenting enhanced nucleotide excision repair activity, reduced cyclobutane pyrimidine dimer accumulation following UV challenge, and antioxidant pathway upregulation in MT-1-treated melanocytes and keratinocytes

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Statement #48: Grade of recommendation D The administration of antioxidants is potentially beneficial for MMA and PA patients, but needs to be confirmed in prospective clinical studies

The observational studies generally reported curvature improvements, plaque reductions, and pain improvement

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