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Multiple copper chelators and copper ionophore have exhibited good anti-tumor properties, indicating that targeting the copper transport system can be used for tumor treatment or increasing the sensitivity of other anticancer drugs

To validate these findings, future work should focus on randomized controlled trials testing integrated lifestyle interventions using functional foods and exercise, with endpoints such as recurrence, inflammation, and quality of life and personalized, omics-guided strategies to match specific dietary and physical activity regimens to individual epigenetic or metabolic profiles

SD, RD, and ZS are employees of Lonza, while KJ is a consultant to Lonza

5.1 Mechanism of intranasal delivery Since William Frey II proposed intranasal administration in 1991 (Frey, 1991), this technique has emerged as a novel, non-invasive delivery system, bypassing the BBB and the systemic first-pass effect, allowing rapid onset of action

For instance, curcumin has been found to stimulate the expression of glutamate-cysteine ligase , the enzyme responsible for initiating glutathione synthesis