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Case 1 illustrates the dramatic effect of derangements in the proper coupling between potassium pump and leak rates (Box 1)

This accumulation causes widespread neuronal dysfunction and death [89]

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The manuscript highlights how DDSsincluding stimuli-responsive nanoparticles, targeted ligands, and biodegradable carriersenhance solubility, bioavailability, and tissue-specific delivery of urate-lowering agents (e.g., allopurinol and febuxostat) and anti-inflammatory therapies (e.g., colchicine and IL-1 inhibitors) (Liu S