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The significant downregulation of the Rb protein increases the vulnerability of hepatocellular carcinoma (HCC) cells to ferroptosis and the efficacy of sorafenib, indicating that the loss of the Rb gene accelerates the progression of ferroptosis (289)

Butyrate plays a central role in maintaining epithelial barrier function, modulating immune responses, and regulating glucose metabolism

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Cancer Res (2013) 73(20):616474

ORLISTAT is intended for patients with a BMI of greater than or equal to 30 kg/m 2 or a BMI of greater than or equal to 27 kg/m 2 in the presence of other risk factors such as hypertension, diabetes, or high cholesterol