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DES has the opposite a tripeptide deletion at the N-terminus that also reduces IGFBP binding but with different receptor-affinity profile and shorter half-life

J Clin Invest (2022) 132(9)

J Neurosci 33:1054410551 Lewis CR, Preller KH, Kraehenmann R, Michels L, Staempfli P, Vollenweider FX (2017) Two dose investigation of the 5-HT-agonist psilocybin on relative and global cerebral blood flow