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The unchanged unwinding rate but elevated processivity is consistent with such an allosteric reduction in the helicase offrate rather than catalytic acceleration driven by such a Mer3-RPA constellation

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Crizotinib, a class Ia small molecule dual inhibitor of c-MET and anaplastic lymphoma kinase (ALK) had been proposed for advanced non-small cell lung cancer therapy with activation of either c-ros oncogene 1 (ROS-1) or ALK [110]

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Exercise-induced bronchoconstriction does not cause eosinophilic airway inflammation or airway hyperresponsiveness in subjects with asthma