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In preclinical research settings, experimental models may examine its role in pathways associated with oxidative stress regulation, detoxification mechanisms, and cellular response systems

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However, a few studies have reported a link between chronic oral ingestion of high doses and the body's intestinal microbiota [7]

Similarly, another meta-analysis reported that the association between eGFR and urinary Cd was statistically insignificant, while the risk of proteinuria rose by only 35% when comparing the highest category of Cd dose metrics with the lowest Cd exposure category [16]

doi:10.1055/s-2006-944219