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The peptide's favorable safety profile in animal studies and its stability across various administration routes have contributed to its growing popularity

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The PGPRs affect plant metabolisms by acting on several mechanisms, including the production of exopolysaccharides, plant hormones, and carotenoids, nitrogen fixation, siderophore, amplified light and CO 2 fixation rates, improved root and shoot system in response to drought stress, They also help in the development of induced systemic tolerance (IST) (Langeroodi et al

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1 Introduction Chronic inflammation is increasingly recognized as a critical contributor to the onset and progression of numerous non-communicable diseases, including cardiovascular disorders, diabetes, neurodegeneration, and various cancers (Nakadate et al., 2025)