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It is possible that NNMT alters histone and DNA methylation status, inducing epigenetic remodeling and metabolism reprogramming (88)

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Rotate between abdomen, outer thigh, and upper arm

For patients without neurological involvement , hydroxocobalamin 1 mg is administered intramuscularly three times a week for 2 weeks, followed by maintenance injections every three months for life (if due to pernicious anaemia or other non-dietary cause)