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5-Amino-1MQ is an orally bioavailable, cell-permeable small molecule that potently inhibits NNMT (nicotinamide N-methyltransferase), the enzyme responsible for methylating nicotinamide to 1-methylnicotinamide (1-MNA)

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doi: 10.1056/NEJMoa072375 126 PandyaNDeMott-FribergRBowersCYBarkanALJaffeCA

Changes in insulin sensitivity induced by short-term growth hormone (GH) and insulin-like growth factor I (IGF-I) treatment in GH-deficient adults are not associated with changes in adiponectin levels

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