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Studies by a team of researchers at PLIVA and the University of Pcs in Hungary found a similar protective effect when they tested pieces of the peptide in freshly isolated rat stomach cells

10.3389/fmed.2023.1157773 319

HMGB1: a new target for ischemic stroke and hemorrhagic transformation

Glutathione deficiency increases vulnerability to oxidative stress and inflammation

If GI symptoms are severe, the solution is slower dose titration (extending intervals between increases from 4 weeks to 68 weeks), eating smaller meals with lower fat content, and potentially adding ginger or vitamin B6 which have anti-nausea effects through different mechanisms