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Large-scale, randomized controlled trials are critically needed to establish definitive efficacy for specific clinical indications and to compare these peptides with established therapies

These changes are often more pronounced than Botox or filler because they are structural (actual collagen remodeling) rather than paralysis or filling

A significant negative association has also been found with the MTHFR C677T polymorphism and leukemias with mixed lineage leukemia (MLL) translocations, but a positive association with hyperdiploidy in infants with ALL or acute myeloid leukemia or with childhood ALL