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10.1016/j.virusres.2012.11.003 139 SchenkP

Earth Space Sci

Its primary biological function is to protect cellular machinery from oxidative stress by neutralizing reactive oxygen species (ROS), such as superoxide radicals and hydrogen peroxide, which are natural but destructive byproducts of cellular energy production

On the other hand, IGFBP-3 undergoes augmented proteolysis on diabetic patients which results in a sudden rise of free IGF-1 concentrations [257, 258]