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Now it's more like one

The 17-oestradiol (E2), the predominant form of ovarian oestrogen produced during the early or mid-follicular phase of the human menstrual cycle 42 (analogous to the morning of the proestrus phase in mice), and progesterone (P4), predominantly produced during the luteal phase (analogous to the evening of the proestrus phase in mice) 21,43,44 , are highly lipophilic hormones capable of crossing the bloodbrain barrier (BBB) 45