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Extensive research has unveiled intricate interactions and mechanisms between the gut and lung infections, encompassing bacterial translocation, short-chain fatty acids, and recognition receptors for pathogen-associated molecular patterns

Moreover, recent clinical studies have shown that HCM-causative FHOD3 mutations increase the risk of cardiovascular death and all-cause death, with the onset of the disease occurring as early as age 4 and as late as age 63 (Vodnjov et al., 2023

Previous studies have well-documented the direct interaction between APP-generated reactive species and isolated proteins, along with their significant impacts on protein functionality 48

Cellular redox signaling, influenced by fluctuations in ROS, RNS, and antioxidant systems, governs vital functions like cell growth, programmed death, and immune responses [112]

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