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Although such response of reactive astrocytes was first described over 100 years ago, there are still many questions and debates remain in the contexts of diseases, recovery, and aging

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This bidirectional mechanism provides a multi-level theoretical basis for targeted metabolic intervention

cf-mtDNA is enriched in unmethylated CpG motifs that activate pattern-recognition receptors such as Toll-like receptor 9 (TLR9), triggering inflammatory and antiviral responses