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Lysine and methionine are essential amino acids that are part of almost all proteins involved in the synthesis of biologically active substances, hormones, enzymes, carnitine, choline, phospholipids, and collagen formation

doi: 10.1038/nature13148

Types of Mutations ( + : decreased expression) or Nonsense mutation Nonsense mutation Types of Mutations ( 0 : absent expression) 2 types of disease variations: Thalassemia minor: heterozygous, approximately 50% decreased synthesis Synthesis Polymerase Chain Reaction (PCR) Thalassemia major: homozygous, no production of globulin, increase in HbA() and HbF(), no HbA Related videos Pathophysiology Defective Hb Hb The oxygen-carrying proteins of erythrocytes

Folate deficiency is also associated with increased levels of these biomarkers, especially homocysteine