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During pregnancy, there is an increase in metabolic activity in the maternal tissues and additional metabolic activity due to the fetus and placenta

The detailed comparison between these two medications helps contextualize why a fresh escalation is safer than attempting dose equivalence

The dependence of highly proliferative cells on glucose as an energy carrier leads to localized lactate accumulation and to acidification of the tissue site

The TCR construct comprises V alpha 34 and V beta 5.1 variable domains fused to minimally-murinized cysteine-modified constant domains to enhance correct pairing of the TCR chains while keeping immunogenicity at a minimum (Fig