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GSH is synthesized via two enzymatic steps that are regulated at multiple levels

The most important SCFAs are butyrate, propionate, and acetate, accounting approximately for 80% of the total, although the production of others like formate and valerate should also be highlighted [188,189,190]

Only through such efforts can we achieve the target diagnostic ensitivity/specificity of 80% essential for cost-effective, stage-specific DPN management

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and whether the ammonia-rich microniches identified in hepatocellular carcinoma represent a phenomenon generalizable to other cancer types remains to be determined