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Stefano GB, Ptacek R, Ptackova H, Martin A, Kream RM

Discussion and perspectives Stem cells with identical genetic information must establish precise spatiotemporal gene expression control mechanisms according to their developmental stage, internal and external conditions, and interactions with surrounding cells

A meta-analysis that included 23 studies with 842 participants of randomized controlled trials that evaluated any biotic intervention in stage 3 to 4 CKD and also ESKD patients revealed that the biotics improved total antioxidative capacity and malondialdehyde and reduced the levels of IL-6

pii: E41

Intracellular lactate can be converted to lactyl-CoA, which serves as the direct high-energy donor for lysine lactylation (Kla)