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Med Phys 33:1738-46, 2006

Data are representative of two separate experiments

In the 2024 WADA Prohibited List (World Anti-Doping Agency, 2024c) Section 4: hormone and metabolic modulators, AIs (Subsection S4.1) and anti-estrogenic substances, including anti-estrogens and SERMs (Subsection S4.2), are prohibited at all times (in- and out-of-competition)

Therefore, restoring TFAM levels by increasing mitochondrial biogenesis and reducing ROS production could protect cardiomyocytes from the oxidative damage of mtDNA induced by I/R-injury (93)