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This will be the first mouse alcohol model having high degree of macrovesicular steatosis in human hepatocytes, alcohol-driven fibrosis mediated by human hepatic stellate cells, and pathological immune responses driven by human Immune cells

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Our screen identified DMF as a small molecule effective in reducing the growth of hypoxic tumor enteroids (Figure 1C)

The balanced and comprehensive approaches such as implementing multidimensional and multi-level systematic evaluation at the animal level, establishing new approaches for alternative research, and providing support for the protection, development, and utilization of endangered medicinal animals help ensure the survival of endangered species while providing valuable knowledge for the scientific community (Chun et al.)