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CINV can also cause weight loss, fatigue, anxiety, treatment non-compliance, and poor treatment outcome (Janelsins 2013

Chu Y.-F., Brown P

KPV has an unusually well-defined mechanism (PepT1 uptake, NF-B/MAPK inhibition) and reproducible anti-inflammatory effects in mouse colitis models

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For example, you can get 100mcg vitamin B12 tablets for 5p each at a supermarket (2.80 for 60, Sainsbury's) compared to a branded version from Solgar which, at 85p a tablet, makes them 17 times more expensive