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The controversial place of vitamin C in cancer treatment

doi: 10.3390/plants8070193

Morita K, Wang F, Patel K, Bueso-Ramos C, IssaGC, Song X, Zhang J, Tippen S, Thornton R, Coyle M, Little L, Gumbs C, Ravandi F, Kadia T, Daver N, Konopleva M, Andreeff M , Cortes JE, Garcia-Manero G, Jabbour EJ, Futreal A, Kantarjian HM, Takahashi

The histidine residues interact strongly with the nickel ions on the chromatography resin, allowing for efficient binding and purification of the protein