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Hepatic safety profiles of emerging systemic therapies Deucravacitinib has demonstrated a favorable hepatic safety profile across multiple clinical trials, with ALT and AST elevations being generally mild, transient, and often related to underlying liver conditions or concomitant medications (Lebwohl et al

[96] demonstrated heterotypic chronic stress (HeCS) could induce visceral hypersensitivity and sensitize colon-specific dorsal root ganglion (DRG) neurons through improving expression of nerve growth factor (NGF) in colonic muscularis externa and mucosa/submucosa

Finally, the distribution of senescent cells varies in different tissues and organs

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