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Doses were usually split across the day and given for at least eight weeks

however, whether other drugs have a regulatory effect on COX-2 expression remains to be determined

A 2-year, randomized, placebo-controlled, double-blind study conducted on 186 patients with end-stage renal disease demonstrated that oral folic acid supplementation (10 mg, 3 times weekly, immediately after each dialysis session) normalized blood Hcy levels in 92.3% of patients but did not reduce the incidence of CV events compared with the placebo group

PMID: 27186831

We believe that this effect is triggered because in the absence of IKE, DHAA can be efficiently reduced to AA due to the constant supplementation of cysteine, which would maintain high levels of GSH