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Beyond these medical requirements, our team also evaluates factors such as cardiovascular stability, metabolic balance, and current medications

Still, our data raise the possibility of several additional nodes of regulation of the CIA in response to cysteine limitation that are worthy of further exploration, including inhibition of cytosolic cluster synthesis due to cysteine insufficiency, restriction of mitochondrial cluster export, or differential cluster integration into recipient proteins through the regulation of the chaperone-based trafficking system 79

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Zeng et al., 2025) and especially in critical illness (Lin et al., 2015) including trauma and sepsis (Larsen et al., 2010)