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In MR, genetic variants are applied as instrumental variables (IVs) to access the potential causal relationship between exposure and outcome due to the random distribution of these variants during meiosis ( Materials and methods Study design An overview of the bidirectional and unidirectional two-sample MR designs is presented in Figure 2

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Key findings revealed that certain TCA cycle enzymes, such as succinate dehydrogenase (SDH) and fumarate hydratase (FH), act as tumor suppressors, establishing direct links between mitochondrial dysfunction and tumorigenesis