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Conclusions: These findings suggest a new link between low peripheral serotonin, L-carnitine, and fatigue

However, the NIMH leaders propose to move from the examination of symptoms to that of systems, social, behavioral, physiological, genetic and, on this basis, to stratify patients into categories organized on the integration of biological data and life experience

Key questions include the onset and course of symptoms, associated symptoms (heartburn, cough, voice changes), triggers, and any weight loss or systemic complaints