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Its clinical applications have been comprehensively reviewed by Frye and Berk (2019), Tenrio et al

Coenzyme Q10supplementation alleviates pain in pregabalin-treated fibromyalgia patientsvia reducing brain activity and mitochondrial dysfunction

For all experiments, if not otherwise stated, DBA1/J female mice (8 weeks old) were used and purchased from Janvier Labs

Hence, assessing an individual adequate dietary intake needs to consider polyphenol's bioavailability, which is different for every molecule, and is a very hard parameter to estimate: in fact, it is deeply affected by intestinal absorption, which can range from 3% of chlorogenic acid up to 43% of caffeic acid [50-51]