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Nevertheless, these studies mainly used disulfide-thiol exchange to deplete GSH for GPX4 inactivation, which is difficult to inactivate GPX4 completely because of the compensatory effect of the continuous synthesis of GSH

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The figure also shows that the selenium-dependent enzyme glutathione peroxidase oxidizes two molecules of glutathione back to GSSG while converting one molecule of hydrogen peroxide (H 2 O 2 ) into two molecules of water (H 2 O)

The Tri-peptide GHK-Cu Ameliorates Acute Lung Injury in Mice