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These approaches include reversing the polarization of M2 macrophages to M1, targeting immune checkpoints using checkpoint inhibitors to rebut T cell responses, and implementing cytokine therapy

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This response requires an immense amount of cellular energy and rapidly burns through the body's stored micronutrients

To ensure the generalizability and reliability of these models, researchers employ validation techniques such as cross-validation and external validation

This design enhances copper delivery to hepatocytes while reducing exposure to nontarget organs, thereby minimizing systemic toxicity