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This mutation results in protein accumulation within the endoplasmic reticulum (ER) of hepatocytes and other AAT-producing cells, which leads to ER stress or an aberrant inflammatory response

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These authors analyzed protein levels in raw plasma from patients whose cognitive status changed from VCD to healed, and vice versa, between recruitment and the six-month follow-up, while the present study evaluated the mRNA levels of these biomarkers in whole blood cultures from volunteers who maintained the same diagnosis between recruitment and the six or 12-month appointment

6G), consistent with the observed downregulation of MYC target genes (Fig