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Acknowledgments We gratefully acknowledge the assistance of Home for Researchers for language modification

Furthermore, when ROS exceeds a certain threshold, it leads to oxidative stress ( Mechanisms governing ferroptosis Ferroptosis, unlike apoptosis, autophagy, and cell necrosis, is a regulatory form of cell death that depends on iron and ROS

Chronic dysregulation of these UPR pathways leads to enhanced cardiomyocyte apoptosis, inflammation, and structural deterioration, forming a key mechanism underlying ER dysfunction in diabetic cardiomyopathy ( 6.2.2 Ca 2+ leakage The ER functions as the main intracellular calcium reservoir

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you cannot live on yogurt and chicken alone