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Carrozza MJ, Li B, Florens L, et al

You can often find detailed breakdowns on platforms like YouTube

M1 macrophages participate in extensive tissue remodeling via the secretion of matrix metalloproteinases upon trophoblast invasion, while M2 macrophages are activated by secreted factors from trophoblasts such as placental-specific glycoproteins (PSGs), M-CSF, TGF-, IL-10, IL-34, and sHLA-G5 and support angiogenesis through the secretion of VEGF

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It's important to note that exact formulations differ between treatments and clinics, so patients should understand what is in their injection for truly informed consent